Caris Life Sciences(R) (Caris), and Xencor, Inc. announced an expansion of their collaboration to research, develop and commercialize novel XmAb(R) bispecific and multi-specific antibodies directed against novel targets, identified and proposed by Caris, for the treatment of patients with cancer. Building upon the initial August 2022 agreement, this expanded collaboration will increase the number of targets and cancer types that Caris will interrogate with its proprietary, multi-omics discovery engine platform, Caris Discovery. Novel targets and their accompanying validation packages will serve as the substrate for drug candidate development through Xencor's XmAb platform.

Under the terms of the new agreement, Xencor will receive exclusive worldwide rights to research, develop and commercialize products directed to up to three targets discovered under the collaboration. Caris will receive an upfront payment and will be eligible to receive up to $187 million in development and commercial milestone payments. Caris will also be eligible to receive royalties on net sales of commercialized products resulting from the collaboration as well as future rights for molecular profiling and companion diagnostics.

Caris Discovery leverages the aggregate strength of Caris' unmatched platform, combining insights generated from the molecular interrogation of primary patient tissues using ADAPT(TM), the company's exclusive aptamer-based proteomic profiling platform; a robust validation pipeline; and the company's proprietary real-world data platform that integrates Caris' extensive catalog of molecular and clinical data. Learn more about Caris Discovery here. XmAb(R) is a registered trademark of Xencor, Inc. About Caris Life Sciences Caris Life Sciences(R) (Caris) is the leading molecular science and technology company actively developing and delivering innovative solutions to revolutionize healthcare and improve patient outcomes.

Through comprehensive molecular profiling (Whole Exome and Whole Transcriptome Sequencing) and the application of advanced artificial intelligence (AI) and machine learning algorithms, Caris has created the large-scale clinico-genomic database and cognitive computing needed to analyze and unravel the molecular complexity of disease. This information provides an unmatched resource and the ideal path forward to conduct the basic, fundamental research to accelerate discovery for detection, diagnosis, monitoring, therapy selection and drug development to improve the human condition. With a primary focus on cancer, Caris' suite of market-leading molecular profiling offerings assesses DNA, RNA and proteins to reveal a molecular blueprint that helps patients, physicians and researchers better detect, diagnose and treat patients.

Caris' latest advancement is a blood-based, circulating nucleic acids sequencing (cNAS) assay that combines comprehensive molecular analysis (Whole Exome and Whole Transcriptome Sequencing from blood) and serial onitoring making it the most powerful liquid biopsy assay ever developed. Headquartered in Irving, Texas, Caris has offices in Phoenix, New York, Denver, Tokyo, Japan and Basel, Switzerland.