Nanocarrier Announces Development of NC-6300 Reaches a New Phase in the U.S. and Commences Administration to Participating Patients
October 01, 2019 at 10:30 pm EDT
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NanoCarrier announced that the development of NC-6300, one of the pipeline products, has reached a new phase in the U.S., and administration to participating patients has commenced. NC-6300 has been designated as an orphan drug in the U.S. and NanoCarrier has been pursuing developmental strategies toward early approval. Epirubicin, an anticancer agent encapsulated in NC-6300, is gaining attention because of its cytotoxic effect as well as its action of inducing the immunogenic cell death. Besides, it is reported that immune-oncology is quite influential to angiosarcoma among several subtypes of soft tissue sarcoma. Therefore, taking into consideration the NC-6300's mechanism of action, NanoCarrier selected angiosarcoma as the target indication of NC-6300. As announced previously, in the US phase I study, two out of two enrolled patients with angiosarcoma achieved partial response (PR), and its performance in the expansion cohort of patients with angiosarcoma is eagerly anticipated. As announced on December 12, 2018, NC-6300 achieved the primary endpoint in the phase I clinical study and NanoCarrier was preparing for the next phase. Previously, NanoCarrier planned to use NC-6300 in combination with olaratumab, a new drug got accelerated approval in the U.S. for the treatment of soft tissue sarcomas, expecting a synergetic effect with micellar nanoparticles. However, in January 2019, Eli Lilly and Company, the supplier of olaratumab, released the results of the phase III clinical study of olaratumab in which the endpoint was not met, and announced in April 2019 that they were preparing to withdraw olaratumab from the market. In association with this, NanoCarrier has elaborated on study design based on various findings through meetings with soft tissue sarcoma experts and the FDA. As a result, NanoCarrier has decided to move forward with the expansion study to confirm the efficacy and safety of NC-6300 monotherapy in patients with angiosarcoma, aiming to ensure probability of approval.
Nano Mrna Co Ltd, formerly NanoCarrier Co Ltd, is mainly engaged in the research and development, manufacturing and sales of pharmaceuticals. The Company develops businesses using the research and development of messenger ribonucleic acid (mRNA) medicine. The products under development are specialized in mRNA medicines. mRNA medicine is a medicine that prevents or treats diseases by administering artificially produced mRNA to the body and allowing the body to discover the protein encoded by the mRNA. Its pipeline includes RUNX1, the mRNA drug pipeline, non-mRNA drug pipeline, Comrex otological liquid 1.5%, NC-6100, TUG1, and others.