The board of directors of CARsgen Therapeutics Holdings Limited announced that the abstracts of zevorcabtagene autoleucel (R&D code: CT053, an autologous CAR-T product against BCMA) and CT071, an autologous CAR T-cell therapy candidate targeting G protein-coupled receptor class C group 5 member D (GPRC5D), have been accepted for oral presentation and poster presentation, respectively, at the 29th Annual Congress of the European Hematology Association ("EHA"). Details are set out below: Abstract Title: PHASE 2 STUDY OF FULLY HUMAN BCMA-TARGETING CAR-T CELLS (ZEVORCABTAGENE AUTOLEUCEL) IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA. Abstract Number: S209.

Publication Type: Oral presentation. Abstract Release Time: May 14, 2024. Abstract Title: FIRST-IN-HUMAN STUDY OF GPRC5D-TARGETED CAR T CELLS (CT071) WITH AN ACCELERATED MANUFACTURING PROCESS IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA (RRMM): Abstract Number: P941.

Publication Type: Poster presentation. Abstract Release Time: May 14, 2024. Zevorcabtagene autoleucel is a fully human, autologous BCMA CAR T-cell product for the treatment of relapsed/refractory multiple myeloma ("R/R MM").

As informed by the NMPA on March 1, 2024, zevorcabtagene autoleucel was approved on February 23, 2024 for the treatment of adult patients with R/R MM who have progressed after at least 3 prior lines of therapy (including a proteasome inhibitor and immunomodulatory agent). CARsgen is conducting a separate Phase 1b/2 LUMMICAR STUDY 2 clinical trial in North America to evaluate the safety and efficacy of zevorcabtagene autoleucel in R/R MM. Zevorcabtagene autoleucel received Regenerative Medicine Advanced Therapy (RMAT) and Orphan Drug designations from the U.S. FDA in 2019, as well as Priority Medicines (PRIME) and Orphan Medicinal Product designations from the European Medicines Agency (EMA) in 2019 and 2020, respectively.

Zevorcabtagene autoleucel also received Breakthrough Therapy designation from the NMPA in 2020. CT071 is a CAR T-cell therapy candidate developed utilizing proprietary CARcelerateTM platform of CARsgen targeting GPRC5D for the treatment of R/R MM or relapsed/refractory plasma cell leukemia ("R/R PCL"). An IIT (NCT05838131) is ongoing in China to evaluate the safety and efficacy of CT071 for the treatment of R/R MM or R/R PCL.