TN-301 First-in-Human Phase 1 Clinical Trial Results and Preclinical Combination Data to be Presented at Heart Failure Society of America Annual
TN-201 Interim Seroprevalence Study Data and Phase 1b Clinical Trial Design to be Featured at Hypertrophic Cardiomyopathy Medical Society Scientific Sessions
TN-301 is Tenaya’s proprietary, highly selective small molecule inhibitor of histone deacetylase 6 (HDAC6) being developed for the potential treatment of heart failure with preserved ejection fraction (HFpEF). Data to be presented at HFSA will include results from the company’s Phase 1 clinical trial of TN-301 in healthy adult participants. Tenaya has previously reported that TN-301 was generally well tolerated and that target engagement was achieved. The company will also present new data from preclinical studies examining the effects of its HDAC6 inhibitor in combination with an approved HFpEF treatment in a model of disease.
TN-201 is Tenaya’s lead gene therapy candidate being developed for the treatment of hypertrophic cardiomyopathy (HCM) caused by mutations in the Myosin Binding Protein C3 (MYBPC3). TN-201 is designed to deliver a fully functional therapeutic MYBPC3 gene to the heart muscle cells. At the HCMS meeting, Tenaya will highlight the clinical trial design for its Phase 1b clinical trial in nonobstructive patients with MYBPC3-associated HCM as well as sharing interim data from an ongoing seroprevalence study.
Details of the presentations are as follows:
2023 HCMS Scientific Sessions
Poster Title: Low Seroprevalence of Neutralizing Antibodies to Adeno-Associated Virus Serotype 9 (AAV9) in Preparation for MyPeak-1, the First-in-Human Study of TN-201, an Investigational AAV9-Mediated Gene Therapy for Individuals with MYBPC3-Associated Hypertrophic Cardiomyopathy (HCM)
Presenter:
Poster Title: MyPeak-1: A Phase 1b Study to Evaluate Safety and Efficacy of TN-201, an Adeno-Associated Virus Serotype 9 (AAV9) Investigational Gene Therapy, in Adults with MYBPC3-Associated Hypertrophic Cardiomyopathy (HCM)
Presenter:
To view full event programming, please visit the 2023 HCMS Scientific Sessions website.
HFSA Annual Meeting 2023
e-Poster: Co-
Presenter: Farshad Farshidfar, M.D., Ph.D., Senior Scientist, Cardiovascular Genetics,
Location: Exhibit Hall ePoster Hub, Monitor 20
ePoster: Phase 1 Clinical Trial Of TN-301, A Highly Selective HDAC6 Inhibitor With Potential In HFpEF, Shows Target Engagement (#417)
Presenter:
Location: General ePoster Viewing Session 7, Exhibit Hall ePoster Hub, Monitor 23
To view full event programming, please visit the HFSA Annual Scientific Meeting 2023 website.
About Tenaya Therapeutics
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