Update on SPARC strategy and portfolio

9th December 2021

BSE:532872 • NSE: SPARC • BLOOMBERG: SPADV@IN • REUTERS: SPRC.BO • CIN:L73100GJ2006PLC047837

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Agenda

01

Portfolio strategy & update

02

Anil Raghavan

03

Anti TAA-1 & other

04

preclinical programs

Nitin Damle

05 Q&A

Clinical NCE assets

Siu-Long Yao

Financial update

Chetan Rajpara

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SPARC - Taking stock of our journey

4 Clinical Stage Programs Targeting Areas of High Unmet Need

Targeting large addressable patient populations with $20B+ combined peak sales potential in 6 indications within Oncology, Neurology & Immunology

Discovery & Development Across Validated & Novel Biology in Order to Balance the Risk

Multi-modal portfolio covering small and large molecules and conjugated entities

10+ preclinical programs including a TAA-1 program expected to enter the clinic in 2023

Proven High Quality R&D Organization with Capital-Efficient Global Operations

350+ scientists across 4 research centers including US; $400M invested to date 2 USFDA approvals for internally developed assets

3 NDAs targeted for submission in 2022

Highly Flexible Model to Maximize Shareholder Value

Partnerships to maximize large commercial potential and provide non-dilutive capital

Maximize multi-TA opportunity and preserve optionality for spin-offs

Experienced Management Team and Globally Recognized Scientific Advisory Board

ADC = Antibody Drug Conjugate | TA = Therapeutic Area | USFDA = United States Food and Drug Administration | NDA = New Drug Approval | TAA-1 = Tumor Associated Antigen-1

SPARC © 2021

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Differentiated operating model

DISCOVERY

Internal Ideation

  • Deliberate process with a robust evaluation framework
  • Mature discovery competency with select partnerships to augment capabilities

Collaborations with academic institutes and biotechs

  • Competitive partnering model
  • Strategic relationships with several Tier 1 academic institutes globally
  • Focus on robust internal validation

DEVELOPMENT

Full service bricks and mortar value chain

Significant global development and manufacturing scale-up experience

Robust Go/No-Go process with substantial experimental and external inputs - Kill early, Kill completely

Opportunities to leverage patient pool in India for quick clinical PoC, biomarker validation and more

COMMERCIALIZATION

Multiple assets out-licensed to partners providing validation for the model

Continue to seek asset- appropriate partnerships

Strategic flexibility to build out own commercial engine in the future or create alternative structure to unlock value

Access high-quality early

Translate efficiently leveraging the

Maximize value capture through

stage science globally

cost and patient arbitrage

fit-for-asset commercial models

Low cost of failure offers multiple shots on goal for invested capital

PoC = Proof of Concept

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Sun Pharma Advanced Research Company Limited published this content on 09 December 2021 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 09 December 2021 08:11:02 UTC.