Summit Therapeutics to Present Research Updates At the 31St Annual ECCMID Conference, Including A Top-Rated ePoster
July 01, 2021 at 08:00 am EDT
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Summit Therapeutics Inc. announced that members of scientific team will present breakthrough research updates at the 31stEuropean Congress of Clinical Microbiology & Infectious Diseases (ECCMID), which will be held virtually July 9 – 12. Three posters to be presented are as follows, one of which was designated as a Top Rated ePoster by the ECCMID conference: ECCMID Top Rated ePoster: Metagenomic Analysis of the Impact of the Precision Antibiotic Ridinilazole, Compared to Vancomycin, on the Gut Resistome in a Phase II Study, Metagenomic Analysis of the Differential Impact of Ridinilazole and Vancomycin on the Gut Microbiota in a Phase II Study, Identification of the Mechanism of Action for Ridinilazole, a Phase III Antibiotic for Treatment of Clostridioides difficile. Ridinilazole is our investigational drug currently in Phase III Ri-CoDIFy clinical trials with the goal of use as first-line therapy to treat initial infection and reduce recurrence of Clostridioides difficile infection. Clostridioides difficile, or C. difficile, infection (CDI) is highly infectious disease that affects over 500,000 patients in the United States each year with approximately 25% of initial cases resulting in recurrent infections. Along with emotional and physical suffering, symptoms include inflammation of the colon, severe watery diarrhea, painful abdominal cramping, nausea, fever, dehydration, and in more severe cases, bowel perforation and sepsis. CDI is responsible for an estimated 20,000 to 30,000 deaths in the US each year with annual acute care costs estimated to be $5.4 billion. Dysbiosis (dysfunction) of the gut microbiota is a major risk factor for initial instances of and recurrence of the disease.
Summit Therapeutics Inc. is a biopharmaceutical company focused on the discovery, development, and commercialization of patient, physician and caregiver medicinal therapies. The Company's development candidate is ivonescimab, a potential first-in-class bispecific antibody intending to combine the effects of immunotherapy via a blockade of PD-1 with the anti-angiogenesis effects of an anti-VEGF compound into a single molecule. It develops ivonescimab in non-small cell lung cancer (NSCLC), specifically launching Phase III clinical trials in the indications such as ivonescimab combined with chemotherapy in patients with epidermal growth factor receptor (EGFR)-mutated, locally advanced or metastatic non-squamous NSCLC who have progressed after treatment with a third-generation EGFR tyrosine kinase inhibitor (HARMONi), and ivonescimab combined with chemotherapy in first-line metastatic squamous NSCLC patients (HARMONi-3). Its ivonescimab is engineered with Akeso's Tetrabody technology.