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Pioneering Solutions for Neurodegenerative Diseases
ProMIS uses Precision Medicine and Artificial Intelligence to develop novel drugs to treat dementia and neurodegenerative diseases
Dementia Disorders
Alzheimer's Disease
Amyotrophic Lateral Sclerosis (ALS)
Parkinson's Disease
Multiple System Atrophy
Lewy Body Dementia
The Challenge: Impaired Cognition
According to the World Health Organization, currently more than 55 million people have dementia worldwide
There are nearly 10 million new cases diagnosed every year1
Dementia is a term for several diseases that affect memory, thinking, and the ability to perform daily activities
Dementia can lead to death, as it affects the brain and other vital organs
Dementia is currently the seventh leading cause of death and one of the major causes of disability and dependency among older people, globally
In the US, Alzheimer's disease, the most common form of dementia, the Alzheimer's Association reported that over 82,000 people died from Alzheimer's disease in 2019
1WHO Fact sheet
Misfolded Proteins: A Leading Cause of Dementia and Neurodegeneration
• Proteins play crucial roles in various cellular functions, and their proper folding is essential for maintaining cellular health.
• However, misfolding, the process in which a protein fails to adopt its correct three-dimensional structure, is a common occurrence.
• Misfolded proteins can arise due to genetic mutations, environmental factors, or errors in cellular processes.
• The gradual and inevitable nature of protein misfolding is part of the aging process
• When proteins misfold, they often lose their functional integrity and may acquire toxic properties.
• Misfolded proteins can aggregate, forming pathogenic clumps that interfere with normal cellular processes.
• These protein aggregates are a hallmark of several neurodegenerative diseases
Normal, healthy protein
(folded structure)Disease associated protein
(misfolded)
Aggregation
Toxic
Image adapted from Racaniello V et al, virology.ws, 2016
Loss of biological function
The ProMIS Solution
ProMIS has created a Novel, Unique, Patent Protected, Targeted platform to:
1. Predict disease-specific misfolding of proteins and identify unique binding sites (epitopes) on each of these misfolded proteins.
2. Create novel antibodies that bind strongly only to the specific epitopes allowing the body's immune system to selectively target and eliminate these toxic proteins from the brain
3. Objective: Slow or Halt Disease Progression
Misfolded proteins are different for each disease. Therefore, the platform can provide highly specific drug candidates for multiple diseases
specific conformational epitope
Ab
Ab binds epitope on misfolded protein
ProMIS Platform has Generated a Robust Pipeline of Selective Antibody/Vaccine Candidates for Toxic Misfolded Proteins
Product Candidate | Target Protein | Disease Indication | Discovery | Pre-Clinical | Phase 1 | Phase 2 | Phase 3 |
PMN310 | Amyloid-Beta | AD | |||||
PMN267 | TDP-43 | ALS | |||||
PMN442 | Alpha-Synuclein | MSA1 | |||||
Discovery | RACK1 | ALS2, HD | |||||
Discovery | Tau | Alzheimer's2, FTLD, PSP, CBD | |||||
Discovery | DISC1+Interactome | Schizophrenia | |||||
Discovery | Amyloid-Beta Vaccine | Alzheimer's Prevention | |||||
Discovery | Alpha-Synuclein Vaccine | Synucleinopathies Prevention |
1 The company plans to investigate additional synucleinopathies, including Parkinson's disease and dementia with Lewy bodies 2Initial indication AD: Alzheimer's disease, ALS: Amyotrophic lateral sclerosis, MSA: Multiple system atrophy, HD: Huntington's disease, FTLD: Frontotemporal lobar degeneration, PSP: Progressive supranuclear palsy, CBD: Corticobasal degeneration
ProMIS Computational Platform and Rational Design Capabilities Enabled the Creation of PMN310
Computational Modeling
Generation of Monoclonal AntibodiesSelection of Lead Candidate
Identification of regions (conformational epitopes) likely to be exposed in misfolded toxic Aβ oligomers but not in monomers or fibrils
Immunization with disease-associated conformational epitope
6-8 months to drug candidates
Copyright 2024, ProMIS Neurosciences, Inc.
Gibbs et al, 2019, Scientific Reports
ProMIS Extensive Patent Estate
• Over 125 total patent filings for entire portfolio, growing
• Global patent estate: Applications have been filed in the US, CA, with the EPO, Japan, and other globally strategic regions
• Extensive patent estate for the amyloid area (PMN310 plus other antibodies)
• 9 issued patents and 43 pending
• Patent coverage for PMN310 in US until 2036, plus potential data exclusivity extensions to 2042
• Three-pronged IP strategy
1. Composition of Matter: Methods & Systems for Predicting Misfolded Peptide Epitopes (two computational algorithms, ProMISTM and Collective Coordinates)
2. Immunogens and methods directed to these disease-specific epitopes
3. Methods of use: antibodies targeting disease specific epitopes, and methods of use thereof
Experienced Leadership Team
Executive Management
Neil K. Warma | Neil Cashman, M.D. | Johanne Kaplan, Ph.D. | Larry Altstiel, M.D., Ph.D. |
Chief Executive Officer | Chief Scientific | Chief Development | Chief Medical Officer |
Officer | Officer |
Gavin Malenfant Chief Operating Officer
David Wishart, Ph.D.
Chief Physics Officer
Eugene Williams, M.B.A.
Neil Cashman, M.D.
Neil K. Warma, M.B.A., B.Sc.
Maggie Shafmaster, Ph.D., J.D.
Chairman and Co-founder
Chief Scientific Officer and Co-founder
Chief Executive Officer
Lead Independent Director
Patrick Kirwin, B.A., J.D.
Josh Mandel-Brehm, M.B.A.
William Wyman, M.B.A.
Independent Director
Independent Director
Independent Director
Board of Directors
Dan Geffken Chief Financial Officer
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ProMIS Neurosciences Inc. published this content on 29 March 2024 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 29 March 2024 11:40:04 UTC.