On February 17, 2023, Pliant Pharmaceuticals, Inc. received notice from Novartis Institutes for BioMedical Research, Inc. that Novartis has elected to exercise its right to terminate the Collaboration and License Agreement by and between the Company and Novartis, dated October 17, 2019 (the “Collaboration Agreement”), as amended by Amendment No. 1 to the Collaboration and License Agreement between the Company and Novartis, dated as of November 15, 2022 (“Amendment No. 1”).

Novartis informed the Company of its decision, as part of its new strategy focusing on a limited number of therapeutic areas, to divest clinical NASH assets and, as a result, to discontinue the development of PLN-1474, a small molecule selective inhibitor of integrin avß1, being developed for the treatment of liver fibrosis associated with NASH. The termination will take effect on April 18, 2023. The Collaboration Agreement provided for an early research program for up to three additional integrin targets (the “Research Targets”).

The research term, as amended by Amendment No. 1, is scheduled to conclude in the first quarter of 2023. During the research term, the Company collaborated with Novartis to biologically validate certain Research Targets and identify and synthesize potential research compounds for each Research Target in accordance with the applicable research plan.

In the second quarter of 2022, the Company successfully validated one of the Research Targets and synthesized multiple potential development candidates. Pursuant to the Collaboration Agreement, the Company received an upfront, non-refundable license fee of $50.0 million and was eligible to receive contingent payments of up to $416.0 million, of which $29.0 million has been received by the Company. Effective upon the termination of the Collaboration Agreement, all rights and licenses granted thereunder, including development candidates targeting the validated Research Target, PLN-1474 and the related IND, will revert back to the Company.

The payment obligations of Novartis with respect to future milestones, royalties and research and development funding will also terminate. The foregoing description of the terms of the Collaboration Agreement and Amendment No. 1 are qualified in their entirety by reference to (i) the Collaboration Agreement, which is filed as Exhibit 10.15 to the Registration Statement on Form S-1 filed with the Securities and Exchange Commission on May 11, 2020 and (ii) Amendment No.

1, which will be filed as an exhibit to the Company's Annual Report on Form 10-K for the year ended December 31, 2022.