Under the terms of the agreement, Ono and PRISM will jointly create a development candidate for Ono's oncology target using PepMetics technology. Upon identification of the development candidate, PRISM will license its rights to Ono for clinical development and commercialization. The deal includes upfront payments, pre-clinical, clinical and commercialization success-based milestones, royalties on future net sales, and other terms. Specific financial terms are not disclosed.
'We highly appreciate PRISM's PepMetics technology in PPI drug discovery', said
'We are very excited to enter into this collaboration with Ono who has a history of creating innovative drugs. ', said
About
About PRISM BioLab
PRISM BioLab is a discovery and development biotechnology company utilizing proprietary PepMetics technology to discover orally available small molecule inhibitors of protein-protein interaction (PPI) targets and transform lives of patients suffering from cancer, autoimmune, fibrosis and other diseases. PepMetics are a unique class of small molecules that mimic three-dimensional structures of alpha-helix and beta-turn, the peptide structures commonly found in intracellular PPI interphases and receptor-ligand interactions. By combining proprietary chemistry, know-how around PPI targets and AI-supported design, PepMetics technology can deliver inhibitors of challenging PPI targets. The technology holds promise to expand the field of drug discovery by turning previously undruggable PPIs into targets readily druggable with small molecules and by generating oral small molecule alternatives for injectable biologics.
PRISM BioLab is collaborating on new PPI targets with global and Japanese pharmaceutical companies. PepMetics targeting CBP/beta-catenin PPIs licensed to
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