RenBiologics business will cover out-licensing/co-development of the company's extensive library of fully human antibodies, as well as licensing of RenMice, the company's fully human antibody/TCR discovery platforms. The RenBiologics logo features an antibody with human-centric design elements, highlighting Biocytogen's expertise in discovering fully human antibodies; the encircled design underscores the company's dedication to becoming a global resource of fully human antibodies to expedite the development of novel antibody-based therapeutics.
Biocytogen's fully human antibody sequences were generated by proprietary RenMice strains, each engineered to lack a certain drug target gene. From
RenMice-derived fully human antibodies can be developed into novel therapies to treat numerous cancers, inflammatory and autoimmune diseases, infectious diseases, metabolic diseases, cardiovascular diseases, and neurological diseases. Target types not only include membrane and extracellular proteins, but also some intracellular proteins, many of which currently lack existing drug treatments. Screened monoclonal antibodies/nanobodies can also be developed as bispecific/multispecific antibodies, cell engagers, bispecific antibody-drug conjugates (bsADCs), and cell therapies. The primary advantage of these antibodies is that they lack the need for artificial humanization, which saves significant cost and accelerates the development process; additionally, for fully human antibodies that exhibit cross-species antigen recognition, preclinical efficacy and safety evaluation can be readily performed in various model species.
Leading biopharmaceutical and biotechnology companies around the world have recognized Biocytogen's vast antibody library. Partnerships with
RenMice Fully Human Antibody/TCR Discovery Platform Licensing Business
Biocytogen offers licensing and flexible partnering models for its RenMice fully human antibody/TCR discovery platforms. RenMice, which were designed using proprietary size-unlimited precise chromosome engineering (SUPCE) technology, includes RenMabTM, RenLite, RenNano, RenTCRTM, and RenTCR-mimicTM platforms to enable discovery of fully human monoclonal antibodies, bispecific antibodies, bsADCs, nanobodies, fully human T-cell receptors (TCRs), and TCR-mimic antibodies with high specificity and affinity. RenMice platform licensing agreements have been established with
Dr. Yuelei Shen, Chairman and CEO of Biocytogen, said, 'Officially establishing the RenBiologics division of our company signifies our commitment to becoming a global headstream of novel antibody-based therapeutics. We will continue to expand our library with best-in-class antibodies against novel targets, and plan to develop and launch novel RenMice platforms to enhance our biologic drug discovery capabilities. We look forward to forging new collaborations and advance existing partnerships into clinic, to ultimately enrich the potential of our partners' pipeline portfolios.'
About Biocytogen
Biocytogen (HKEX: 02315) is a global biotechnology company that drives the research and development of novel antibody-based drugs with innovative technologies. Founded on gene editing technology, Biocytogen leverages genetically engineered proprietary RenMice platforms for fully human monoclonal/bispecific/multispecific antibody discovery, bispecific antibody-drug conjugate discovery, nanobody discovery and TCR-mimic antibody discovery, and has established a sub-brand, RenBiologics, to explore global partnerships for an off-the-shelf library of >400,000 fully human antibody sequences against approximately 1000 targets. As of
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