PENTIXAPHARM
INVESTOR PRESENTATION
Highly concentrated version
Confidential
FALL 2023
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Disclaimer
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THIS COMMUNICATION CONTAINS MARKET DATA RELATED TO OUR BUSINESS AND INDUSTRY. SUCH MARKET DATA INCLUDES PROJECTIONS THAT ARE BASED ON A NUMBER OF ASSUMPTIONS. IF ANY OF OUR ASSUMPTIONS PROVE TO BE INCORRECT, OUR ACTUAL RESULTS MAY SIGNIFICANTLY DIFFER FROM OUR PROJECTIONS BASED ON THESE ASSUMPTIONS. THE ASSUMPTIONS WE HAVE USED IN MAKING THESE STATEMENTS ARE THOSE WE BELIEVE ARE REASONABLE AND MOST SIGNIFICANT TO THE PROJECTIONS AS OF THE DATE OF THIS COMMUNICATION. TO THE EXTENT THAT OUR ASSUMPTIONS AND OTHER ASSUMED EVENTS DO NOT MATERIALIZE, OUR ACTUAL RESULTS MAY VARY SUBSTANTIALLY FROM THE PROJECTED OPERATING AND FINANCIAL INFORMATION, INCLUDING OUR PROJECTED FINANCIAL STATEMENTS, PERFORMANCE OR RESULTS, CONTAINED IN THIS COMMUNICATION.
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To harvest the full potential
of CXCR4
EZAG seeks co-investors
Act as | Provide | Focus on | Assist in IPO | Provide know- | Technically a |
sparring- | clinical | value | preparation | how in | "Series B" |
partners to | development | creation | business | Investment | |
EZAG and | know-how | development | |||
PentixaPharm | |||||
team |
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What Does PTX Offer?
- Significant short-term revenue generation through late-stage,therapy-enablingGa68-CXCR4
- Phase-III-readyfor marginal zone lymphoma in Europe
- Phase-III-readinesspending for hypertension in US
Use of Ga-68-CXCR4 for HYPERTENSION represent a first-in-class medical breakthrough
- World class clinical pipeline targeting billion-dollar markets
- Rheumatoid Arthritis with TAM > 7 billion USD
- Recurrent Epithelial Ovarian Cancer with TAM > 5 billion USD
- Myelomas and leukaemia as promising next therapy areas
- 2nd generation, value-adding diagnostics for hypertension, haemato-oncology and muscle invading bladder cancer.
- A theragnostic play outside the overfunded PSMA/ NET crowd
- Abundant clinical evidence
- established supply chains
- Experienced entrepreneurial team with proven track record
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Needed for Cash Break-Even: 65 M€
Deployable for pipeline: 250 M€
The quick way to sales revenues and financial self-sustainability
PRIMARY
HYPERALDOSTERONISM
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Primary Aldosteronism is a Major Cause of Hypertension
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https://www.diasorin.com/sites/default/files/allegati_prodotti/ese_spin_brochure_rev._03_low.pdf
Cumbersome Diagnostics Prevent Million of Treatments
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Main Challenge/ Bottleneck:
Adrenal Venous Sampling
Complicated, CT guided vein sampling
Adrenal Venous Sampling:
- Essential for distinguishing unilateral (curable) from bilateral (uncurable) cases.
- Extremely challenging technical procedure
- Succes rates vary between 8 and 61%
- Low sensitivity (high rate of false positives)
- Low specificity (reason for gradient vary)
Pentixapharms PET-Scan will
Eliminate the Bottleneck
Favourable Health Economics and Outcome Research (HEOR)
- Ga-68-CXCRmore specific and more sensitive than AVS
- Based on current IIS clinical data
- Cost advantage of Ga-68-CXCR over AVS > 15,000 USD per patient
- Surgical procedure substituted with a PET-scan
- Income loss to surgeons from AVS decline likely compensated by larger volume of adrenalectomies
- Significant OSHA advantages of Ga-68-CXCR over AVS
- Eliminates radiation exposure (from CT) for surgeons
- In proportion, Ga-68-CXCR4 to benefit African-Americans more1
- Relevant for reimbursement/ FIND Act
10 | 1REasons for Geographic And Racial Differences in Stroke (REGARDS) study |
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Disclaimer
Eckert & Ziegler AG published this content on 26 November 2023 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 28 November 2023 15:40:29 UTC.