Eckert & Ziegler AG

Dr. Harald Hasselmann, CEO

Eigenkapitalforum 2023

Disclaimer

This presentation contains forward-looking statements based on the beliefs of Eckert & Ziegler AG management. Such statements reflect current views of Eckert & Ziegler AG with respect to future events and results and are subject to risks and uncertainties. Actual results may vary materially from those projected here, due to factors including changes in general economic and business conditions, the introduction of competing products, lack of market acceptance of new products, services or technologies and changes in business strategy. Eckert & Ziegler AG does not intend or assume any obligation to update

these forward-looking statements.

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All information contained in this presentation or webinar is provided without guarantee of accuracy,

completeness or currency. Any contractual obligation and/or liability in connection with the presentation or webinar, including vis-à-vis third parties, is excluded. Slides only for illustration, the spoken word shall be binding.

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2

New Management Board (from January 2024)

Dr. Harald Hasselmann

Jutta Ludwig

Frank Yeager

Chairman of the Executive Board

Member of the Executive Board

Member of the Executive Board

Segment Medical

Asia Business

Segment Isotope Products

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Core Competences - In the Middle of an Expanding Specialty Pharma Market

(Approval

Date)

Companion Theragnostic

Radiopharmaceuticals

Beta Therapeutic

Radiopharmaceuticals

(2022)

(2018)

(2018)

Alpha Therapeutic Pharmaceuticals

(2013)

Selected Pipeline

Companies

Unpaired Diagnostic

(2022)

(2021)

Selected Pipeline

Companies

Radiopharmaceuticals(2021)

(2020)

(2016)

(2016)

(2011)

Selected Pipeline

FDG

(2000)

Companies

(1994)

(1990)

No claim to completeness

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The Nuclear Medicine Market - Development and its Pillars

Estimated Nuclear Medicine Market Size 2030: 30BN USD *

Financing Rounds &

Investments 2023

Clinical Trials for radiotherapeutics

Success of Approved

Drug Products

1.4BN USD

175M USD

20

2

0

4

1

Expected Sales Growth 2022 2023

Pluvicto®+160%

UP TO 425M USD

142M USD

152M USD

105M USD

100M USD

90M USD

47,7M EUR

2023 2024 2025 2026

Phase 1

Phase 1/2

Phase 2

Phase 3

Expected time from Phase 3 to commercialization: 1 year

(Selected Data 2023 - No Claim To Completeness )

Lutathera®+30%

Illuccix®+118%

* MedRays Intell 2020

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Core Competences - Sustainably Targeting Market Developments

Gallium-68

"The Companion Diagnostic Isotope"

  • Market Leader in Ga-68 generators
  • Prerequisite for therapy patient selection

30BN

USD

Lutetium-177

"The Therapeutic Isotope of the Moment"

  • EMA approval Q2/2024
  • Broadly used (Pluvicto & Lutathera)
  • Further drug products to be approved soon (2025)

Yttrium-90

"Pushing Medical Devices"

  • Global core supplier for Y-90
  • APAC Expansion ongoing

Actinium-225

"The Next Big Therapy Isotope"

  • Pioneer: GMP grade Q1/2024
  • Various trials ongoing with first commercial drug in 2028

Equipment & Services

"Facilitators & Enablers"

  • Global radiopharmaceutical manufacturing
  • Provision of infrastructure & equipment incl. hot cells

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Core Competences - Radioisotope Supply, Related Services and Equipment

Radio- pharmaceutical Development

Raw Material

Radioisotopes

Imaging

Sources

Radio- pharmaceutical Manufacturing

Industrial Measurement

Healthcare Professionals

Quality

Assurance

Patients

Scientific

Applications

Services and Equipment provided by Eckert & Ziegler

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7

Q3 2023 Operational Highlights

JUL 2023

SEP 2023

SEP 2023

SEP 2023

Letter of Intent for

CMO for

Collaboration with

Supply of POINT

Co-Development

SCINTOMICS

RefleXion Medical

Biopharma with

with PMB Alcen

Molecular, att

and Telix

Lutetium-177

Agreement to jointly

Long-term collaboration to

Agreement to jointly

Agreement with a term of

develop a cutting-edge

produce disposable

develop Satellite Hot Labs

ten years and total sales

solution for the scalable

consumables for SCI-att's

for on-demand labeling of

volume of more than € 100

synthesis of

proprietary GRP

tracers for biology-guided

million

radiotherapeutic agents

radiosynthesis platform.

radiotherapy

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EZAG in a Nutshell

ISOTOPE PRODUCTS

Radiation

Sources

Services

Trade

Disposal

MEDICAL

Medical Devices

Pharmaceuticals

Lab Devices

Engineering

CMO / CDMO

OTHERS

Group Items / Pipeline

Holding

Pentixapharm

Myelo

Special Projects

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Segment Data (FY2022)

Isotope Products

  • ~ 580 employees
  • Revenue: 131,4 million EUR

Rev. / Employee: 234.000 EUR

Revenue

EBIT

  • EBIT: 21,5 million EUR

59%

41%

46%

54%

Medical

  • ~ 300 employees
  • Revenue: 90,9 million EUR
  • Rev. / Employee: 304.000 EUR
  • EBIT: 25,5 million EUR

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Eckert & Ziegler AG published this content on 24 November 2023 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 28 November 2023 13:01:30 UTC.