The FTSE 100 <.FTSE> marked its second week of losses as a worldwide sell-off took the shine off risky assets, and Thursday's bounce proved to have little staying power.

The index ended the session 0.1 percent lower with a loss of 0.7 percent on the week, tracking weakness in European markets. Mid-caps <.FTMC> fell 0.3 percent, also seeing a second week of losses.

Corporate news drove the most attention-grabbing moves, from Sky on the blue-chip index to Carillion among small-caps.

Pay-TV firm Sky (>> Sky) shot more than 4 percent higher to the top of the FTSE after sources said Comcast Corp (>> Comcast Corporation) and Verizon Communications (>> Verizon Communications) had expressed interest in acquiring part of Rupert Murdoch's Twenty-First Century Fox Inc's (>> Twenty-First Century Fox) assets.

"Comcast's interest in the 39 percent stake in Sky seems plausible," said Liberum analysts. "Its NBC Universal has publicly stated its interest in expanding its non-U.S. assets for a number of years and the UK is a key market for many of the U.S. media groups."

The U.S. groups' interest demonstrates Fox's stake in Sky is still seen as a valuable asset, Liberum added. Sky shares enjoyed their best day in nearly a year.

Downgrades and disappointing results sent the broader market lower.

Small-cap construction firm Carillion (>> Carillion) collapsed more than 48 percent after a third profit warning set it up to breach debt covenants at the end of the year.

"The Carillion horror show continues," said Nicholas Hyett, equity analyst at Hargreaves Lansdown.

"Shorts who stayed the course, even adding, will be grinning all the way to the bank, having expected already serious corporate and financial troubles to worsen," said Mike van Dulken, head of research at Accendo Markets.

Back on the FTSE 100, Mediclinic (>> Mediclinic International) fell for a second day as investors digested the South African private hospital group's admission it had not yet reached a deal for its much anticipated takeover of Spire Healthcare Group (>> Spire Healthcare Group PLC).

Shire (>> Shire) fell 1.8 percent after shooting up 6 percent on Thursday when rival Roche's haemophilia drug was given a black box warning by the U.S. FDA.

A downgrade from HSBC sent United Utilities (>> United Utilities) down 4.4 percent, the sharpest large-cap fall. Analysts at the bank said the utility's earnings would be dented by rising inflation.

"We expect earnings to be adversely affected by the current high levels of RPI as it has 53 percent of its total debt index-linked," they wrote in a note.

(Reporting by Helen Reid and Kit Rees; Editing by Mark Potter)

By Helen Reid