For personal use only

Appendix 3Y

Change of Director's Interest Notice

Rule 3.19A.2

Appendix 3Y

Change of Director's Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX's property and may be made public.

Introduced 30/09/01 Amended 01/01/11

Name of entity Rhythm Biosciences Limited

ABN

59 619 459 335

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director

Otto Buttula

Date of last notice

9 September 2021

Part 1 - Change of director's relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of "notifiable interest of a director" should be disclosed in this part.

Direct or indirect interest

Indirect

Nature of indirect interest

1)

Newfound Investments Pty Ltd

(including registered holder)

Note: Provide details of the circumstances giving rise to the relevant

interest.

2)

Webinvest Pty Ltd

Date of change

25 November 2021

  • See chapter 19 for defined terms. 01/01/2011 Appendix 3Y Page 1

Appendix 3Y

Change of Director's Interest Notice

No. of securities held prior to change

1)

Newfound Investments Pty Ltd

only

2)

11,001,667 fully paid ordinary shares

Webinvest Pty Ltd

(ASX: RHY)

134,167 Unlisted options

(ASX: RHYAK) expiring 31 August 2022

134,167 Unlisted options

(ASX: RHYAL) expiring 31 July 2024

use

17,083,334 fully ordinary paid shares

(ASX: RHY)

208,334 Unlisted options

(ASX: RHYAK) expiring 31 August

2022

208,334 Unlisted options

personalFor

(ASX: RHYAL) expiring 31 July 2024

Class

Unlisted options (ASX: RHYAI) expiring

31 July 2024

Number acquired

2,000,000

Number disposed

Nil

Value/Consideration

Refer to Notice of Meeting lodged with

Note: If consideration is non-cash, provide details and estimated

ASX on 20 October 2021 for further

valuation

information.

+ See chapter 19 for defined terms.

Appendix 3Y Page 2

01/01/2011

For personal use only

Appendix 3Y

Change of Director's Interest Notice

No. of securities held after change

1) Newfound Investments Pty Ltd

11,001,667 fully paid ordinary shares

(ASX: RHY)

134,167 Unlisted options

(ASX: RHYAK) expiring 31 August 2022

134,167 Unlisted options

(ASX: RHYAL) expiring 31 July 2024

2,000,000 Unlisted options (ASX:

RHYAI) expiring 31 July 2024

2) Webinvest Pty Ltd

17,083,334 fully ordinary paid shares

(ASX: RHY)

208,334 Unlisted options

(ASX: RHYAK) expiring 31 August

2022

208,334 Unlisted options

(ASX: RHYAL) expiring 31 July 2024

Nature of change

2,000,000 unlisted options issued via

Example: on-market trade, off-market trade, exercise of options,

shareholder approval received on 24

issue of securities under dividend reinvestment plan, participation in

November 2021 -

buy-back

refer to Notice of Meeting lodged with

ASX on 20 October 2021.

Part 2 - Change of director's interests in contracts

Note: In the case of a company, interests which come within paragraph (ii) of the definition of "notifiable interest of a director" should be disclosed in this part.

Detail of contract

n/a

Nature of interest

Name of registered holder (if issued securities)

Date of change

No. and class of securities to which interest related prior to change

Note: Details are only required for a contract in relation to which the interest has changed

  • See chapter 19 for defined terms. 01/01/2011 Appendix 3Y Page 3

For personal use only

Appendix 3Y

Change of Director's Interest Notice

Interest acquired

Interest disposed

Value/Consideration

Note: If consideration is non-cash, provide details and an estimated valuation

Interest after change

Part 3 - +Closed period

Were the interests in the securities or contracts detailed n/a above traded during a +closed period where prior written clearance was required?

If so, was prior written clearance provided to allow the trade to proceed during this period?

If prior written clearance was provided, on what date was this provided?

+ See chapter 19 for defined terms.

Appendix 3Y Page 4

01/01/2011

For personal use only

Appendix 3Y

Change of Director's Interest Notice

Rule 3.19A.2

Appendix 3Y

Change of Director's Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX's property and may be made public.

Introduced 30/09/01 Amended 01/01/11

Name of entity Rhythm Biosciences Limited

ABN

59 619 459 335

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director

Lou Panaccio

Date of last notice

9 September 2021

Part 1 - Change of director's relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of "notifiable interest of a director" should be disclosed in this part.

Direct or indirect interest

Indirect

Nature of indirect interest

Tercus Pty Ltd

(including registered holder)

Note: Provide details of the circumstances giving rise to the relevant

interest.

Date of change

25 November 2021

No. of securities held prior to change

Held by Beneficial interest through

Tercus Pty Ltd:

820,000 fully paid ordinary shares (ASX:

RHY)

10,000 Unlisted options (ASX: RHYAK)

expiring 31 August 2022

10,000 Unlisted options (ASX: RHYAL)

expiring 31 July 2024

  • See chapter 19 for defined terms. 01/01/2011 Appendix 3Y Page 1

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Rhythm Biosciences Ltd. published this content on 25 November 2021 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 25 November 2021 06:49:06 UTC.