Rhythm Biosciences Limited

Appendix 4D

Half-Year report

1. Company details

Name of entity:

Rhythm Biosciences Limited

ABN:

59 619 459 335

only

For the half-year ended 31 December 2021

Reporting period:

Previous period:

For the half-year ended 31 December 2020

2. Results for announcement to the market

2021

2020

use

$

$

Up 118% to

2,433,429

1,118,772

Oth r income from ordinary activities

Loss from ordinary activities after tax attributable to the owners of

Rhythm Biosciences Limited

Up 110% to

(4,220,697)

(2,013,923)

Comprehensive loss for the year attributable to the owners of Rhythm

Biosciences Limited

Up 110% to

(4,220,697)

(2,013,923)

Dividends

There were no dividends paid, recommended or declared during the period.

personal

Comments

Comments on activities during the half-year are included in the Directors' Report in the Interim Financial Report attached.

3. Net tangible assets

Reporting

Previous

period

period

Cents

Cents

Net tangible assets per ordinary security

2.33

2.82

4. Control gained over entities

The Company established a 100% owned USA domiciled entity, IchorDX Inc, with the intent on accelerating international expansion activities.

For5. Loss of control over entities

Not applicable.

6. Details of associates and joint venture entities

Not applicable.

Rhythm Biosciences Limited

Appendix 4D

Preliminary final report

7. Audit qualification or review

Details of audit/review dispute or qualification (if any):

onlyThe financial statements have been reviewed and an unqualified conclusion has been issued.

8. Attachments

Details of attachments (if any):

The Interim Financial Report of Rhythm Biosciences Limited for the half-year ended 31 December 2021 is attached.

9. Signed

use

Date: 25 February 2022

Glenn Gilbert

personalFor

Managing Director

For personal use only

RHYTHM BIOSCIENCES

LIMITED

(ASX: RHY)

INTERIM FINANCIAL REPORT

TO 31 DECEMBER 2021

Rhythm Biosciences Limited

Corporate Directory

31 December 2021

Directors

onlyCompany secretary Registered office

useShare register

A ditor

personalStock exchange listing For

Mr Otto Buttula (Executive Chairman)

Mr Glenn Gilbert (Managing Director)

Dr Trevor John Lockett

Mr Louis (Lou) James Panaccio

Mr Eduardo Vom

Dr Rachel David

Ms Andrea Steele

Bio21 Molecular Science & Biotechnology Institute 30 Flemington Road

Parkville VIC 3010 Australia

+ 61 3 8256 2880 (Phone)

Link Market Services Limited

QV1, Level 12, 250 St. Georges Terrace

Perth WA 6000

BDO Audit Pty Ltd

Collins Square

Tower 4

Level 18, 727 Collins Street

Melbourne VIC 3008

Rhythm Biosciences Limited shares are listed on the Australian Securities Exchange (ASX code: RHY)

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Rhythm Biosciences Limited

Contents

31 December 2021

Directors' report Review of operations

Auditor's independence declaration

onlyStatement of profit or loss and other comprehensive income Statement of financial position

Statement of changes in equity Statement of cash flows

Notes to the financial statements Directors' declaration

Independent auditor's review report to the members of Rhythm Biosciences Limited

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5

7

8

9

10

11

12

16

17

General information

useThe financial statements cover Rhythm Biosciences Limited as a consolidated entity consisting of Rhythm Biosciences Limited and the entities it controlled at the end of, or during, the half-year. The financial statements are presented in Australian dollars, which is Rhythm Biosciences Limited's functional and presentation currency.

Rhythm Biosciences Limited is a listed public company limited by shares, incorporated and domiciled in Australia. Its registered office and principal place of business is:

Bio21 Molecular Science & Biotechnology Institute

30 Flemington Road personalP rkville VIC 3010

For

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Rhythm Biosciences Ltd. published this content on 24 February 2022 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 25 February 2022 00:00:01 UTC.