To whom it may concern

April 23, 2024

Nissan Chemical Corpora�on

SANWA KAGAKU KENKYUSHO CO., LTD.

Nissan Chemical and Sanwa Kagaku Kenkyusho

Announce Signing of Strategic Collabora�on Agreement to Discover

and Develop Oligonucleo�de Therapeu�cs

Nissan Chemical Corpora�on (Head office Chuo-ku, Tokyo Japan, President: Shinsuke Yagi) and Sanwa Kagaku Kenkyusho Co., Ltd. (Head officeNagoya city, Aichi Japan, President Shusaku Isono jointly announced today the signing of a strategic collabora�on agreement to discover and develop oligonucleo�de therapeu�cs for severe rare diseases with significant unmet medical needs.

Under the collabora�on, Nissan Chemical and Sanwa Kagaku will collaborate on drug discovery research to iden�fy poten�al novel oligonucleo�de therapeu�cs. Nissan Chemical will design and synthesize oligonucleo�de molecules against gene targets selected by both par�es while Sanwa Kagaku will be responsible for efficacy and toxicity studies based on their remarkable track record in drug development.

The companies have already discovered a preclinical an�sense candidate for a rare disease with no treatment op�ons under their drug discovery collabora�on agreement concluded in March 2019. Considering this achievement, Nissan Chemical and Sanwa Kagaku expand into the strategic collabora�on to advance next-genera�on oligonucleo�de therapeu�cs programs.

Nissan has established the oligonucleo�de pla�orm with its proprietary oligonucleo�de technology such as a novel modified nucleic acid "MCE" and a single-stranded heteroduplex oligonucleo�de "ss-HDO" to develop oligonucleo�de therapeu�cs with high efficacy and safety.

About Nissan Chemical Corpora�on

Nissan Chemical Corpora�on contributes to solving social issue providing products and services through four business areas - Performance materials, Agricultural chemicals, Chemicals, and Healthcare. We will acquire new technologies and accelerate growth in each business area by improving and combining core technologies.

Addi�onal informa�on is available at www.nissanchem.co.jp/.

About Sanwa Kagaku Kenkyusho Co., Ltd.

Sanwa Kagaku Kenkyusho Co., Ltd. is a subsidiary of Suzuken Co., Ltd. who is one of the Japanese leading pharmaceu�cal wholesalers. We provide sa�sfactory drugs and diagnos�c agents in the area of diabetes and kidney diseases. Our corporate philosophy is "Human- friendly 'medicines' for people in the world" and we offer services aimed at improving the quality of life of people wishing for good health.

Addi�onal informa�on is available at www.skk-net.com.

Contact information for inquiries on the above

Nissan Chemical Corporation

Corporate Planning Department

Planning Office, Public Relations Group

Sanwa Kagaku Kenkyusho Co., Ltd.

Corporate Strategy Department

CSR Public Relations Group

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Nissan Chemical Corporation published this content on 23 April 2024 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 23 April 2024 04:07:01 UTC.