On March 17, 2021, the Board of Directors (the “Board”) of Global Blood Therapeutics, Inc. (the “Company”) appointed Alexis A. Thompson, M.D., M.P.H., to the Board as a Class I director. Dr. Thompson was appointed to a newly created vacancy resulting from an increase in the size of the Board from nine to ten directors. She will serve on the Board’s research and development (R&D) committee. A board-certified pediatric hematologist, Dr. Thompson is head of the Hematology Section and director of the Comprehensive Thalassemia Program at the Ann and Robert H. Lurie Children’s Hospital of Chicago, where she also serves as the A. Watson and Sarah Armour Endowed Chair for Childhood Cancer and Blood Disorders.