On March 26, 2019, Charles Homcy, M.D., a member of the board of directors of Global Blood Therapeutics, Inc. (the Company), notified the Company that he intends to resign from the Board, including the Research and Development Committee of the Board on which he currently serves, effective as of the Company’s next annual meeting of stockholders, which is expected to be held on June 18, 2019 (the “Annual Meeting”), and accordingly, he will not stand for re-election at the Annual Meeting.