Item 1.02. Termination of Material Definitive Agreement.

On April 21, 2023 Aptinyx, Inc. (the "Company") completed voluntary prepayment of all outstanding principal, accrued and unpaid interest, fees, costs and expenses, equal to $27.4 million in the aggregate (the "Payoff Amount"), under the Loan and Security Agreement (the "Loan Agreement"), dated as of September 15, 2021 by and among the Company, the several banks and other financial institutions or entities from time to time parties to the Loan Agreement (collectively, the "Lenders"), and K2 HealthVentures LLC, in its capacity as administrative agent and collateral agent for itself and the Lenders. The Payoff Amount includes a prepayment charge of $0.8 million equal to 3.0% of the outstanding principal, and an exit fee of $1.6 million. Upon receipt by the Lender of the Payoff Amount on April 21, 2023, all obligations, covenants, debts and liabilities of the Company under the Loan Agreement were satisfied and discharged in full, and the Loan Agreement and all other documents entered into in connection with the Loan Agreement were terminated.

The Loan Agreement provided for a term loan with aggregate maximum borrowings of up to $50.0 million (the "Term Loan"). Under the Loan Agreement, the Company borrowed $25.0 million. The Term Loan bore interest at a variable annual rate equal to the greater of (i)(a) 4.70% plus (b) the Prime Rate (as reported in the Wall Street Journal) and (ii) 7.95%. Interest-only payments on the borrowings under the Loan Agreement were due through September 1, 2023. After the interest-only payment period, borrowings under the Loan Agreement were due in equal monthly payments of principal and accrued interest until September 1, 2025.

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