On June 10, 2019, Scott A. Canute, a Class I Director, notified Akebia Therapeutics, Inc. of his intention to resign from the company’s Board of Directors for personal reasons, effective as of June 10, 2019. The company and Mr. Canute entered into a consulting agreement, effective as of June 10, 2019, pursuant to which Mr. Canute will provide certain consulting services to the company.