Morgan Stanley & Co. Int'l plc

AMENDMENT Section (2a)

FORM 8.5 (EPT/RI)

PUBLIC DEALING DISCLOSURE BY AN EXEMPT PRINCIPAL TRADER WITH RECOGNISED INTERMEDIARY STATUS DEALING IN A CLIENT-SERVING CAPACITY

Rule 8.5 of the Takeover Code (the 'Code')

1. KEY INFORMATION

(a) Name of exempt principal trader:

Morgan Stanley & Co. International plc

(b) Name of offeror/offeree in relation to whose relevant securities this form relates:

Use a separate form for each offeror/offeree

Shire plc

(c) Name of the party to the offer with which exempt principal trader is connected:

Shire plc

(d) Date dealing undertaken:

23 APRIL 2018

(e)Has the EPT previously disclosed, or is it today disclosing, under the Code in respect of any other party to this offer?

Yes -Takeda Pharmaceutical Company Limited

2. DEALINGS BY THE EXEMPT PRINCIPAL TRADER

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(b), copy table 2(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

The currency of all prices and other monetary amounts should be stated.

(a) Purchases and sales

Class of relevant security

Purchases/sales

Total number of securities

Highest price per unit paid/received

Lowest price per unit paid/received

ADR

PURCHASES

1,433

160.9391 USD

160.9391 USD

ADR

SALES

1,433

160.9391 USD

160.9391 USD

5p ordinary

PURCHASES

1,733,961

38.9700 GBP

37.8550 GBP

5p ordinary

SALES

1,588,926

38.9488 GBP

37.8500 GBP

(b) Cash-settled derivative transactions

Class of relevant security

Product description

e.g. CFD

Nature of dealing

e.g. opening/closing a long/short position, increasing/reducing a long/short position

Number of reference securities

Price per unit

ADR

CFD

LONG

113

160.0800 USD

ADR

CFD

LONG

2,111

160.0800 USD

ADR

CFD

LONG

359

160.0800 USD

ADR

CFD

LONG

2,111

160.0800 USD

ADR

CFD

LONG

359

160.0800 USD

ADR

CFD

LONG

118

160.2900 USD

ADR

CFD

LONG

579

160.2900 USD

ADR

CFD

LONG

540

160.2900 USD

ADR

CFD

LONG

220

160.5045 USD

ADR

CFD

LONG

30

160.7900 USD

ADR

CFD

SHORT

220

158.6818 USD

ADR

CFD

SHORT

579

160.0800 USD

ADR

CFD

SHORT

984

160.0800 USD

ADR

CFD

SHORT

540

160.0800 USD

ADR

CFD

SHORT

644

160.0800 USD

ADR

CFD

SHORT

486

160.0800 USD

ADR

CFD

SHORT

908

160.2900 USD

ADR

CFD

SHORT

908

160.2900 USD

5p ordinary

CFD

LONG

34

38.0000 GBP

5p ordinary

CFD

LONG

1,000

38.0000 GBP

5p ordinary

CFD

LONG

181

38.0000 GBP

5p ordinary

CFD

LONG

13

38.0000 GBP

5p ordinary

CFD

LONG

2,590

38.0927 GBP

5p ordinary

CFD

LONG

1,584

38.0927 GBP

5p ordinary

CFD

LONG

2,905

38.0927 GBP

5p ordinary

CFD

LONG

3,074

38.0927 GBP

5p ordinary

CFD

LONG

2,783

38.0927 GBP

5p ordinary

CFD

LONG

17,660

38.0988 GBP

5p ordinary

CFD

LONG

40,170

38.1688 GBP

5p ordinary

CFD

LONG

485

38.2200 GBP

5p ordinary

CFD

LONG

76,634

38.2319 GBP

5p ordinary

CFD

LONG

59,722

38.3046 GBP

5p ordinary

CFD

LONG

3,829

38.3617 GBP

5p ordinary

CFD

LONG

196

38.4879 GBP

5p ordinary

CFD

LONG

317

38.5111 GBP

5p ordinary

CFD

LONG

157

38.5111 GBP

5p ordinary

CFD

SHORT

485

38.0000 GBP

5p ordinary

CFD

SHORT

196

38.0000 GBP

5p ordinary

CFD

SHORT

2,694

38.0000 GBP

5p ordinary

CFD

SHORT

6,418

38.0000 GBP

5p ordinary

CFD

SHORT

6,417

38.0000 GBP

5p ordinary

CFD

SHORT

1,516

38.0000 GBP

5p ordinary

CFD

SHORT

4,010

38.0000 GBP

5p ordinary

CFD

SHORT

67,071

38.0658 GBP

5p ordinary

CFD

SHORT

219

38.0970 GBP

5p ordinary

CFD

SHORT

78,907

38.2299 GBP

5p ordinary

CFD

SHORT

12,289

38.2306 GBP

5p ordinary

CFD

SHORT

15,665

38.2306 GBP

5p ordinary

CFD

SHORT

317

38.2432 GBP

5p ordinary

CFD

SHORT

867

38.2432 GBP

5p ordinary

CFD

SHORT

22

38.2820 GBP

5p ordinary

CFD

SHORT

120

38.2888 GBP

5p ordinary

CFD

SHORT

150

38.3017 GBP

5p ordinary

CFD

SHORT

58,091

38.3334 GBP

5p ordinary

CFD

SHORT

2,273

38.3334 GBP

5p ordinary

CFD

SHORT

182

38.3398 GBP

5p ordinary

CFD

SHORT

304

38.3398 GBP

5p ordinary

CFD

SHORT

1,807

38.3398 GBP

5p ordinary

CFD

SHORT

6,600

38.4781 GBP

5p ordinary

CFD

SHORT

21

38.5027 GBP

5p ordinary

CFD

SHORT

65,300

38.5648 GBP

5p ordinary

CFD

SHORT

47,300

38.5735 GBP

5p ordinary

CFD

SHORT

10,800

38.6068 GBP

5p ordinary

CFD

SHORT

800

38.6750 GBP

5p ordinary

CFD

SHORT

1,000

38.8086 GBP

(c) Stock-settled derivative transactions (including options)

(i) Writing, selling, purchasing or varying

Class of relevant security

Product description e.g. call option

Writing, purchasing, selling, varying etc.

Number of securities to which option relates

Exercise price per unit

Typee.g. American, European etc.

Expiry date

Option money paid/ received per unit

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

(ii) Exercise

Class of relevant security

Product descriptione.g. call option

Number of securities

Exercise price per unit

N/A

N/A

N/A

N/A

(d) Other dealings (including subscribing for new securities)

Class of relevant security

Nature of dealinge.g. subscription, conversion

Details

Price per unit (if applicable)

N/A

N/A

N/A

N/A

The currency of all prices and other monetary amounts should be stated.

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(b), copy table 2(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

3. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the exempt principal trader making the disclosure and any party to the offer or any person acting in concert with a party to the offer:

If there are no such agreements, arrangements or understandings, state 'none'

None

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the exempt principal trader making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state 'none'

None

Date of disclosure:

25 APRIL 2018

Contact name:

Craig Horsley

Telephone number:

+44(141) 245 7736

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service and must also be emailed to the Takeover Panel atmonitoring@disclosure.org.uk. The Panel's Market Surveillance Unit is available for consultation in relation to the Code's dealing disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.

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Shire plc published this content on 25 April 2018 and is solely responsible for the information contained herein. Distributed by Public, unedited and unaltered, on 25 April 2018 13:12:12 UTC