Wall Street had opened higher, as the Dow breached the 26,000 mark for the first time. The healthcare sector, up 0.46 percent, provided support to the upside, with Merck (>> Merck and Company) up 5.8 percent and UnitedHealth (>> UnitedHealth Group) up 1.9 percent.

UnitedHealth posted quarterly results that topped analyst estimates and raised its 2018 outlook, bolstering optimism for another solid quarter for corporate earnings.

Earnings growth for the quarter is forecast at 11.9 percent, according to Thomson Reuters data through Tuesday morning.

But each of the major Wall Street indexes fell into negative territory as materials <.SPLRCM>, down 1.2 percent and energy <.SPNY>, off 1.2 percent, slumped.

Market participants cited skittishness over a possible U.S. government shutdown at the end of the week as the impetus behind the pullback in areas that have rallied of late.

"Look at what has happened to commodities, the dollar has collapsed, commodities have exploded, they have done nothing but go straight up," said Ken Polcari, Director of the NYSE floor division at O’Neil Securities in New York.

"The minute there is any catalyst that makes anyone a little bit nervous they take some money in the really good performers."

Oil prices eased from three-year highs as traders booked profits from the rally but healthy demand underpinned prices near $70, a level not seen since 2014's market slump.

U.S. crude settled down 0.9 percent at $63.73 per barrel and Brent was last at $69.15, down 1.6 percent on the day.

Copper lost 1.37 percent to $7,111.50 a tonne, touching a 3-1/2 week low following strong gains late last year and as worries lingered over fading demand in China.

The Dow Jones Industrial Average <.DJI> fell 10.33 points, or 0.04 percent, to 25,792.86, the S&P 500 <.SPX> lost 9.8 points, or 0.35 percent, to 2,776.44 and the Nasdaq Composite <.IXIC> dropped 37.38 points, or 0.51 percent, to 7,223.69.

Citigroup (>> Citigroup) shares rose 0.4 percent to $77.11 after earnings topped expectations, the latest major U.S. bank to post results for the fourth quarter. The S&P financial index <.SPSY> is up nearly 5 percent to start the year.

Shares in Europe closed little changed as commodity stocks also weighed.

The pan-European FTSEurofirst 300 index <.FTEU3> percent and MSCI's gauge of stocks across the globe <.MIWD00000PUS> shed 0.09 percent after hitting a record for a third straight session.

The euro held close to a three-year high against the dollar on Tuesday, as the common currency recovered from earlier losses tied to doubts that the European Central Bank would back away from its pledge to keep buying bonds at next week's meeting, up 0.03 percent to $1.2265 while the dollar remained near three-year lows.

U.S. long-dated Treasury yields edged up as equities retreated. Benchmark 10-year notes last rose 3/32 in price to yield 2.5426 percent, from 2.552 percent late on Friday.

(Editing by Chizu Nomiyama and Nick Zieminski)

By Chuck Mikolajczak

Stocks treated in this article : Citigroup, Merck and Company, UnitedHealth Group